A novel function for Cyclin A2: Control of cell invasion via RhoA signaling
نویسندگان
چکیده
منابع مشابه
A novel function for Cyclin A2: Control of cell invasion via RhoA signaling
Cyclin A2 plays a key role in cell cycle regulation. It is essential in embryonic cells and in the hematopoietic lineage yet dispensable in fibroblasts. In this paper, we demonstrate that Cyclin A2-depleted cells display a cortical distribution of actin filaments and increased migration. These defects are rescued by restoration of wild-type Cyclin A2, which directly interacts with RhoA, or by a...
متن کاملFKBP51 regulates cell motility and invasion via RhoA signaling
FK506 binding protein 51 (FKBP51), a member of the immunophilin family, is involved in multiple signaling pathways, tumorigenesis, and chemoresistance. FKBP51 expression correlates with metastatic potential in melanoma and prostate cancer. However, the functions of FKBP51, particularly involving the regulation of cell motility and invasion, are not fully understood. We discovered two novel inte...
متن کاملRhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling
OBJECTIVE Epidermal stem cells (ESCs) play a critical role in wound healing, but the mechanism underlying ESC proliferation is not well defined. Here, we explore the effects of RhoA on ESC proliferation and the possible underlying mechanism. METHODS Human ESCs were enriched by rapid adhesion to collagen IV. RhoA(+/+)(G14V), RhoA(-/-)(T19N) and pGFP control plasmids were transfected into human...
متن کاملDown-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.
Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest...
متن کاملA Novel Self-tuning Zone PID Controller for Temperature Control via a PLC code
S7-1200 with Tia Portal technology has become a Standard function of distributed controlsystems. Self-Tuning methods belong to Programmable Controllers (PLC) techniques. PLCtechniques contain software packages for advanced control based on mathematical methods. S7-1200 tools are designed to increase the Process Capacity, yield, and quality of products. Most ofthe present time digital industry r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2012
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.201102085